Slide 2 of 5 of Coagulación sanguínea. VÍA EXTRÍNSECA; 2. Vía Intrínseca; 3. Conversión de la Vías y cascada de la coagulación. Enzimas que actuan en la coagulación.c. Asignatura: .. Al final, las vías intrínse cas y extrínsecas confluyen en una secuencia de etapas en común. hasta. Los factores de la coagulación de la vía extrínseca se activan al producirse el La coagulación también puede activarse por la vía intrínseca al entrar en.

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This is the first report of anticoagulant activity in Anadyomene stellataLobophora variegata and Liagora farinosa. The extract of L.

These molecules have different degree of sulfate in their structure and therefore are capable of substitute heparin Farias et al. Naito K, Fujikawa K Apr Thrombosis and Haemostasis 86 1: One of the extracts of C. An International Journal in Haemostasis and Thrombosis 16 4: Materials and methods The samples for this study were manually collected from the seven localities described above, from the Gulf of Mexico and Mexican Caribbean sea during May to October figure 1were classified by genus and transported frozen to the laboratory using solid CO 2.

Developments in Comparative Immunology 9: In the laboratory the material was thawed at room temperature and a fraction of this was preserved in glycerinated formaldehyde for species determination and Voucher organisms, this specimens were kept in our laboratory as internal reference material. It is relevant to point out the dependence of anticoagulant potency due to the locality where algae grows, also the date of collection and thus, the climate season is other factor that could influence the synthesis of compounds, particularly in the brown alga Lobophora variegata we observed the double anticoagulant action in sample collected in May ofbut six months later Novembersame specie only was active in the prothrombin time test.


The results showed other algae with slightly inhibition of clot formation activity, it is not common to consider this species for further investigation, nevertheless the retardation of formation of clot by Penicillus capitatusa species evolutionary related to Halimeda genus Vroom et al.

A total of five species were active in standard clotting test, three of Chlorophyta, one from Phaeophyta and one from Rhodophyta.

Acscada algal material was rinsed with tap water and distilled water. Anadyomene stellataCaulerpa cupressoides ChlorophytaLobophora variegata Phaeophyta y Liagora farinosa Rhodophyta. The results showed that four species presented potent anticoagulant activity same as heparin in the two pathways: Journal of Phycology Vistas Leer Editar Ver historial.

Agardh, Caulerpa cupressoides West in Vahl C. De Wikipedia, la enciclopedia libre. Rhamnan sulfate from cell walls of Monostroma latissimum.

coagulación – English Translation – Word Magic Spanish-English Dictionary

The mixture was homogenized in a Waring blender, centrifuged at x g inntrinseca 15 minutes and supernatant filtered through 0. The discovery of alternative anticoagulant molecules must be an important task for scientists. American Fxtrinseca of Human Genetics 48 5: Current views on blood coagulation and haemostatic mechanism. Anadyomene stellataCaulerpa cupressoides ChlorophytaLobophora variegata Phaeophyta and Liagora farinosa Rhodophyta.

This is the case of extracts of Anadyomene stellata, Caulerpa cupressoides, Lobophora variegata and Liagora farinosa. Pharmacological activities of marine algae. Similar results of slightly anticoagulant potency were observed but in thrombin time test for C. Thrombosis is a health problem that affects many people in the world. This fact makes the discovery of new anticoagulant substances a priority issue in research.

It has been done research in anticoagulant activity of polysaccharides and glycosaminoglycans of diverse sources such as: Niveles elevados de factor XI han sido implicados en casos de trombosisaunque es incierto que es lo que determina estos niveles, y cuan severo puede ser el estado procoagulante.

Detección de sustancias anticoagulantes en algunas macroalgas marinas

Thrombosis and Haemostasis 98 1: Anticoagulant, fibrinolytic and antiaggregant activity of carrageenans and alginic acid. The extracts were prepared mixing 10 g fresh weight of algal material and 10 ml of phosphate buffer PB 0. Consultado el 7 de abril de Revista de la Sociedad Mexicana de Historia Natural A simple method of studying the generation of thrombin in recalcificated plasma.


Forty nine seaweed species collected off shore of several localities of Gulf of Mexico and Mexican Caribbean sea were screened in order to detect anticoagulant activity in both intrinsic and extrinsic pathways of clot formation. Finally, sample collected in April of change the anticoagulant activity extrinsefa active only in the thrombin time test.

Factor de coagulación XI

Comparative Biochemistry and Physiology Extrinseac Agardh, ChlorophytaLobophora variegata Lamoroux Womersley Phaeophyta and Liagora farinosa Lamouroux Rhodophyta were as potent as heparin impeding the clot formation in both thrombin and prothrombin time tests. As anticoagulant time reference 6. Caulerpa paspaloides Chlorophyta was active only in the thrombin time test.

Results for algal extracts in both anticoagulant tests are in table 1.

Epiphytes were removed carefully from the algae under the microscope to avoid contamination. Biochemical and Biophysical Research Communications 2: Highly sulfated dermatan sulfates from ascidians. The extracts could act preventing the conversion of prothrombin to thrombin, also they could act stopping the transformation of fibrinogen to convert it to fibrin o even in the polymerization of this last molecule.

These variation has been suggested as been influenced by geographical factors such as climate and locality and has been probed with primary metabolites as lectins by Ingram and Fabregas et al.