PDF | The present study aims to evaluate the therapeutic properties of the medicinal plants (Vitex negundo, Aegle marmelos and Boswellia serrata) for their . Abstract To evaluate the anti-inflammatory activity of Vitex negundo (VN) leaf extract and its mechanism of action in experimental animals. Carrageenin induced. Abstract. The present study was undertaken to assess the anti-inflammatory effect of ethanolic extract of Vitex negundo roots in rats.

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DX 7 days, orally as standard drug.

Vitex negundo and Murraya koenigii are popular Indian herbs which are used for various clinical disorders. X 7 days orally and Ibuprofen mg kg -1 B. Shri Satguru Publication 3: The filtrates were kept on water bath to obtain the crude extract [ 10 ].

Used by Winter et al. Pathological Basis of Disease. The plant material and preparation of extract: CDepartment of Biochemistry, for allowing us to perform bio-chemical investigation in the department.

The vitamin-C and carotene content of several herbs and flowers used in ayurvedic system of medicine.

Ayurvedic drugs and their plant sources. Total yield of extract was In the method studied for mechanism of anti-inflammatory activity, against acute inflammation, the VN extract in different dose concentration 0. The maximum anti-inflammatory action was observed in 3 h in all the doses of test drug.


Antioxidant and Antiinflammatory Activity of Vitex negundo.

The anti-inflammatory activity in this dose was also comparable with Ibuprofen mg kg -1 B. Non-steroidal anti-inflammatory drugs; p. Mice were fasted overnight before the day of experiment and the liver was promptly excised after sacrificing the mice.

Each response was recorded for 30 sec. VN extract was administered orally in graded dosesand mg kg -1 as single dose therapy and twice daily for 7 day in respective inflammatory experimental models.

It is also useful in leucoderma and negunfo disorders. Carrageenan-induced paw edema being an in-vivo investigational model for acute inflammation which been extensively used to determine the anti-inflammatory effect of new investigational agents. Therefore, the present study was undertaken to investigate anti-inflammatory activity and mechanism of action of ethanolic leaf extract of VN Linn. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders.

Abstract Reactive inlammatory species are implicated in various inflammatory disorders.

Antioxidant and Antiinflammatory Activity of Vitex negundo

Proceedings of the international workshop, Lucknow: Department of Pharmacognosy and Phytochemistry, Principal K. Statistical analysis was carried out by applying student’s t-test. Stabilization of the Prussian blue colour in the determination of polyphenols. Robbins, Pathologic Basis of Disease.

Medicinal uses and biological activities of Vitex negundo. Isolation ihflammatory 4, 4′-dimethoxy-trans-stilbene and flavonoids from leaves and twigs of Vitex negundo Linn.

Kundnani College of Pharmacy. The plant was collected from local area of Sevagram in the month of June, DX 7 days, orally showed significant reduction of both wet as well as dry weights of granuloma in dose dependent manner, when compared to control with maximum effect in mg kg neegundo dose of the test drug showing National Center for Biotechnology InformationU. The experiment was repeated for ten times.


Extracts were prepared in order to study their anti-inflammatory activity. Oct 06, Abstract Vitex negundo and Murraya koenigii are popular Indian negnudo which are used for various clinical disorders.

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Histomorphological changes induced by Vitex negundo in albino rats. Okuma, Steiner M, Baldini M. Screening of anti-inflammatory activity of certain indigenous drugs on carrageenin induced hind paw oedema in rats. Similarly, fresh leaves of VN have been suggested to possess anti-inflammatory and pain suppressing activities possibly mediated via PG synthesis inhibition, antihistamine, membrane stabilising and antioxidant activities Dharmasiri et al.

Footnotes Kulkarni, et al.: Therefore, it can be assumed that the inhibitory effect of the polyherbal extract of Vitex Negundo and Murraya Koenigii on carrageenan-induced inflammation could be due to the inhibition of activit enzyme cyclooxygenaseleading to the inhibition of prostaglandin synthesis. Support Center Support Center. Pain and Inflammatory Mediators in Inflammation.

Cycloxygenase 1 and inflammarory.